At Twist Bioscience, we combine precise oligonucleotide synthesis with a scalable silicon-based manufacturing platform to generate high-performing probe panels for NGS target enrichment.
We also complement this powerful technology with proprietary design algorithms and a rapid iteration pipeline to enable the quick design, synthesis, and optimization of custom panels.
Twist Custom Panels can be designed and built to cover a wide range of panel sizes, target regions, and multiplexing requirements — all with the exceptional and consistent performance you’ve come to expect from Twist NGS solutions.
With our incredibly flexible design capabilities, you can easily expand or enhance content on your existing panel or blend together the content from multiple panels with the Twist Custom Blended Panels option. This unprecedented flexibility saves you time while guaranteeing high-quality performance and analysis.
Whether you design your own panel from scratch or add targets to enhance the content of existing panels, you can use your Twist Custom Panel with Twist’s modular library preparation kits or seamlessly integrate them into an existing workflow.
KEY BENEFITS
- Effective design, accurate synthesis, and detailed quality control maximize both uniformity of capture and reproducibility
- High-fidelity double-stranded DNA probes offer high-quality, consistent performance
- NGS-based quality control of all probes ensures balanced probe representation and minimizes dropout
- Fast turnaround time to final panel
- Simple addition or enhancement of content without sacrificing performance
- Ensures adjustment of workflow biases for optimum performance
- Scalable design from 100 to >1M probes per pool
- Reduces the iterations to final design
- Enables balanced capture, even for challenging regions
